Lysosomal storage disorders (LSDs) are inborn metabolic abnormalities characterized by the excessive accumulation of substrates in a variety of organ cells as a result of lysosome dysfunction. They contribute significantly to significant morbidity and mortality by causing malfunction in the organs where they accumulate. Dubbed as one of the most prevalent leukodystrophies in 2020, MLD has a prevalence rate of 1 occurrence in 40,000–160,000 births worldwide. Now what is metachromatic leukodystrophy? Metachromatic leukodystrophy (MLD) is a lysosomal storage disorder. The inability to break down sulphated glycolipids, particularly the galactosyl-3-sulphate ceramides is one of its defining characteristics. It is brought on […]
